Any kind of work done with synthetic or treated materials where you're heating or abrading them should be done with good ventilation and I don't mean just opening a window or something. If you want to ventilate an area well one thing you can do is open a window on one end and put a fan in a doorway or other window to help create positive pressure to vent any fumes or dust. It's a technique that's used for ventilation of smoke and toxic gases in structural firefighting.
FWIW Your typical home hobbyist is probably not working with the volume of materials to be immediately life threatening. It's the exposure to those chemicals or dust over long periods of time that can cause problems. The amounts of hazardous materials a firefighter encounters is way higher in a single exposure than most people will experience in a whole lifetime.